What is Huntington’s Disease?

What is Huntington’s Disease (HD)?

Huntington’s disease is a devastating, hereditary, degenerative brain disorder for which there is, at present, no cure.  HD slowly diminishes the affected individual’s ability to walk, talk, and reason.  Eventually the individual with HD becomes totally dependent on others for his or her care.  Huntington’s disease profoundly affects the lives of entire families-emotionally, socially and economically.

Named for Dr. George Huntington, who first described this hereditary disorder in 1872, HD is now recognized as one of the more common genetic disorders.  More than a quarter of a million of Americans have HD or are “at risk” of inheriting the disease from an infected parent.  HD affects as many people as Hemophilia, Cystic Fibrosis, or muscular dystrophy.

Early symptoms of HD affect cognitive ability or mobility and include depression, mood swings, forgetfulness, clumsiness, involuntary twitching and lack of coordination.  As the disease progresses, concentration and short-term memory diminish and involuntary movements of the head, trunk and limbs increase.  Walking, speaking and talking abilities deteriorate.  Eventually the person is unable to care for him or herself.  Death follows from complications such as choking, infection or heart failure.

HD typically begins in mid-life, between the ages of 30 and 50, though onset may occur as early as age 2.  Children who develop the juvenile form of the disease rarely live to adulthood.

HD affects males and females equally and crosses all racial and ethnic boundaries.  Each child of a person with HD has a 50/50 chance of inheriting the fatal gene.  Everyone who carries the gene will develop the disease.  In 1993, the HD gene was isolated and a direct genetic test was developed which can accurately determine whether a person carries the HD gene.  The test cannot predict when symptoms will begin.  However, in the absence of a cure, some individuals “at risk” elect not to take the test.

Since the discovery of the gene that causes HD, scientific research has accelerated and  much has been added to our understanding of Huntington’s Disease and its effects upon different individuals.  By continuing to increase investment in both clinical and basic HD research each year, breakthroughs in treatment-and a cure can be forthcoming.

If you would like to help find a cure there are so many creative ways to give and make a difference!  Please go to the Huntington’s Disease Society of America website and it click DONATE today!

http://www.hdsa.org

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